Shireen Seno was born to a Filipino family in Japan, where she spent most of her childhood. She graduated from the University of Toronto with a BA in Architectural Studies and Cinema Studies. She started out in film shooting stills for Lav Diaz and John Torres before going on to direct her debut feature, Big Boy, which premiered at Rotterdam 2013 and went on to screen at international film festivals. Big Boywas the opening film of Hors Pistes Tokyo, organized by the Centre Pompidou, and won the prize for Best First Film at the Festival de Cine Lima Independiente.

2012 Big Boy
2014 Shotgun Tuding (short)
2018 Nervous Translation